Scientists identify live immune cells in a coral and sea anemone — ScienceDaily

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A new study led by scientists at the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science and the Ben Gurion University of the Negev has identified specialized immune cells in the cauliflower coral and starlet sea anemone that can help fight infection. The findings are important to better understand how reef-building corals and other reef animals protect themselves from foreign invaders like bacteria and viruses found in and around coral reefs.

The researchers found that immune cells make up about three percent of the total cell population and that they have at least two populations of immune cells that perform functions unique from digestion.

“These findings are important because they show that corals have the cellular capabilities to fight infection and that they have unique cell types that were previously not known,” said Nikki Traylor-Knowles, an assistant professor of marine biology and ecology at the UM Rosenstiel School and co-senior author of the study.

To uncover these specialized immune cells, the researchers exposed foreign particles such as bacteria, fungal antigens, and beads into a cauliflower coral (Pocillopora damicornis) and starlet sea anemone (Nematostella vectensis) in the laboratory. They then used a process, called fluorescence-activated cell sorting, to isolate different cell populations.

They found that specialized cells, known as phagocytic cells, engulfed the foreign particles, while small, fluid-filled structures inside the cells, called phagosomes, worked to destroy the invaders as well as their own damaged cells.

Immune systems in animals provide an important protective defense response to recognize and destroy foreign substances in their tissues.

“We need to have a better understanding of how coral cells perform specialized functions such as fight infections as the climate change crisis drastically reduces global coral reef biomass and diversity worldwide,” said Traylor-Knowles. “Our findings can help in the development of diagnostic tools for assessing coral health.”

Support for the study was provided by seed funding from the University of Miami Research Awards in Natural Sciences and Engineering, National Science Foundation-U.S.-Israel Binational Science Foundation grants (NSF grant: 1951826, BSF grant: 2019647), the Israel Science Foundation, European Research Council and Human Frontiers Science Program.

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Materials provided by University of Miami Rosenstiel School of Marine & Atmospheric Science. Original written by Diana Udel. Note: Content may be edited for style and length.